CD14

Across TCGA cell cohorts, CD14 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD14-associated genes across cancer lineages are MS4A4A, LCE1C, and TMEM114. Each is linked with CD14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD14-to-partner and partner-to-CD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by CD14-low versus CD14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD14→partner) and Y-score (partner→CD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.188	+3.678	<.001	.009	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	TMEM114 →	+0.044	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MS4A4A by CD14 expression — LARGE_INTESTINE

Explore this box plot interactively →