CCZ1B

Across TCGA patient cohorts, CCZ1B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCZ1B-associated genes across cancer lineages are 14-3-3_beta, EGFR, and eIF4E. Each is linked with CCZ1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CCZ1B-to-partner and partner-to-CCZ1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CCZ1B-low versus CCZ1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCZ1B→partner) and Y-score (partner→CCZ1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.119	-3.432	.001	.005	3	1
UCEC	EGFR →	-0.129	-1.678	.035	.023	3	1
UCEC	eIF4E →	+0.196	+2.087	.015	.005	3	1
UCEC	eIF4G →	+0.295	+2.087	.013	.005	3	1
UCEC	A-Raf_pS299 →	-0.108	-2.459	.018	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.415	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by CCZ1B expression — UCEC

Explore this box plot interactively →