CCZ1B

Across TCGA cell cohorts, CCZ1B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCZ1B-associated genes across cancer lineages are PRAMEF7, MOGAT1, and ZAN. Each is linked with CCZ1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CCZ1B-to-partner and partner-to-CCZ1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF7 grouped by CCZ1B-low versus CCZ1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCZ1B→partner) and Y-score (partner→CCZ1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRAMEF7 →	+0.012	+5.539	.001	.003	3	1
LARGE_INTESTINE	MOGAT1 →	+0.170	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	ZAN →	+0.011	+4.204	<.001	<.001	3	1
LARGE_INTESTINE	SAXO1 →	+0.045	+3.556	.001	.007	3	1
LARGE_INTESTINE	PLA2G2E →	+0.287	+3.584	<.001	.004	3	1
LARGE_INTESTINE	LINGO4 →	+0.156	+3.869	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRAMEF7 by CCZ1B expression — BLOOD_Leukemia

Explore this box plot interactively →