CCT8

Across TCGA pan-cancer cohorts, CCT8 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CCT8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CCT8 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCT8 is over-expressed in tumor.

LSCC, COAD, and CCRCC are the cancer types where CCT8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCT8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.381	<.001	9	view →
COAD	Male	III,IV	+0.277	<.001	9	view →
CCRCC	All	III,IV	+0.181	<.001	9	view →
LUAD	Male	III,IV	+0.318	<.001	8	view →
HNSC	All	III,IV	+0.166	<.001	8	view →
PDAC	Male	All	+0.169	.015	5	view →
OV	All	All	+0.283	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CCT8–LSCC

Open the LSCC breakdown →