CCT8

Across TCGA patient cohorts, CCT8 protein abundance is significantly associated with the RNA expression of many other genes, with 14,323 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CCT8-associated genes across cancer lineages are DEPDC1, TRIP13, and BIRC5. Each is linked with CCT8 in more than 6 cancer types. Because this analysis shows association rather than direction, both CCT8-to-partner and partner-to-CCT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCT8 versus DEPDC1 in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT8→partner) and Y-score (partner→CCT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEPDC1 →	+0.966	+0.201	<.001	.001	3	7
LUAD	TRIP13 →	+1.040	+0.231	<.001	<.001	3	7
BRCA	BIRC5 →	+1.166	+0.212	<.001	.001	3	7
BRCA	CXCL12 →	-1.457	-0.238	<.001	<.001	3	6
PDAC	NCAPG →	+0.894	+0.180	<.001	<.001	3	6
UCEC	KIF20A →	+0.963	+0.171	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,323 associations by consensus.

CCT8 vs DEPDC1 — UCEC

Explore this scatter interactively →