CCT8

Across TCGA cell cohorts, CCT8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,762 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCT8-associated GO terms across cancer lineages are DNA replication initiation, Attachment of spindle microtubules to kinetochore, and Nucleolar large rRNA transcription by RNA polymerase I. Each is linked with CCT8 in more than 19 cancer types. Because this analysis shows association rather than direction, both CCT8-to-partner and partner-to-CCT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by CCT8-low versus CCT8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT8→partner) and Y-score (partner→CCT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.200	+0.753	<.001	<.001	3	20
KIDNEY	Attachment of spindle microtubules to kinetochore →	+0.141	+0.668	<.001	<.001	3	18
BLOOD_Myeloma	Nucleolar large rRNA transcription by RNA polymerase I →	+0.123	+0.598	<.001	<.001	3	18
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.122	+0.737	<.001	<.001	3	18
BONE	Kinetochore assembly →	+0.156	+0.704	.003	.001	3	17
BONE	DNA-templated DNA replication →	+0.138	+0.870	.006	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,762 associations by consensus.

DNA replication initiation by CCT8 expression — BONE

Explore this box plot interactively →