CCT8

Across TCGA cell cohorts, CCT8 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible CCT8-associated genes across cancer lineages are FTMT, SPRR2F, and ADGRE3. Each is linked with CCT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT8-to-partner and partner-to-CCT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by CCT8-low versus CCT8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT8→partner) and Y-score (partner→CCT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	SPRR2F →	+0.176	+4.635	<.001	.003	3	1
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	1
KIDNEY	OR13C4 →	+0.023	+5.000	<.001	.005	3	1
KIDNEY	OR4F6 →	+0.056	+5.000	<.001	.005	3	1
BLOOD_Leukemia	KRTAP3-1 →	+0.028	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FTMT by CCT8 expression — SOFT_TISSUE

Explore this box plot interactively →