CCT6B

Across TCGA patient cohorts, CCT6B mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT6B-associated genes across cancer lineages are TRAJ12, CCDC75P1, and RNU4-16P. Each is linked with CCT6B in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT6B-to-partner and partner-to-CCT6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by CCT6B-low versus CCT6B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT6B→partner) and Y-score (partner→CCT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRAJ12 →	+0.852	+4.193	<.001	.009	3	2
LUSC	CCDC75P1 →	+0.087	+4.067	.002	.001	3	2
LUSC	RNU4-16P →	+0.266	+4.733	<.001	.004	3	2
LUSC	RPS12P24 →	+0.291	+3.875	<.001	.004	3	2
LUSC	MTND6P12 →	+0.053	+4.191	.009	.009	3	2
LUSC	XKRY2 →	+0.013	+6.924	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

TRAJ12 by CCT6B expression — CESC

Explore this box plot interactively →