CCT6B

Across TCGA patient cohorts, CCT6B mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT6B-associated genes across cancer lineages are VHL, Caspase-7-cleavedD198, and GSK-3_pS9. Each is linked with CCT6B in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT6B-to-partner and partner-to-CCT6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CCT6B-low versus CCT6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT6B→partner) and Y-score (partner→CCT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.546	-1.807	.025	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.576	+1.894	.006	.030	3	2
UCEC	GSK-3_pS9 →	-0.338	-2.000	.020	.029	3	1
UCEC	JNK2 →	+0.175	+1.584	.014	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.163	+1.598	.028	.011	3	1
UCEC	Myosin-IIa →	+0.157	+2.595	.024	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

VHL by CCT6B expression — UCEC

Explore this box plot interactively →