CCT6A

Across TCGA patient cohorts, CCT6A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT6A-associated genes across cancer lineages are JNK2, Lck, and Notch1. Each is linked with CCT6A in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT6A-to-partner and partner-to-CCT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CCT6A-low versus CCT6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT6A→partner) and Y-score (partner→CCT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.206	+1.700	.014	.044	3	1
UCEC	Lck →	+0.188	+1.700	.027	.044	3	1
UCEC	Notch1 →	+0.128	+3.013	.031	.018	3	1
UCEC	Rad50 →	-0.207	-2.222	.044	.011	3	1
UCEC	ATM →	-0.625	-2.222	.001	.011	3	1
UCEC	4E-BP1 →	+0.388	+3.351	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by CCT6A expression — UCEC

Explore this box plot interactively →