CCT6A

Across TCGA cell cohorts, CCT6A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,886 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCT6A-associated GO terms across cancer lineages are DNA replication initiation, DNA-templated transcription termination, and Maturation of SSU-rRNA. Each is linked with CCT6A in more than 14 cancer types. Because this analysis shows association rather than direction, both CCT6A-to-partner and partner-to-CCT6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by CCT6A-low versus CCT6A-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT6A→partner) and Y-score (partner→CCT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.217	+1.155	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription termination →	+0.116	+1.049	<.001	.007	3	15
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.124	+0.776	<.001	<.001	3	14
BLOOD_Myeloma	Protein localization to kinetochore →	+0.131	+0.839	.003	.001	3	14
BONE	Ribosome biogenesis →	+0.103	+0.672	<.001	<.001	3	14
BONE	Ribosomal small subunit biogenesis →	+0.149	+1.003	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,886 associations by consensus.

DNA replication initiation by CCT6A expression — BLOOD_Myeloma

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