CCT5

Across TCGA patient cohorts, CCT5 mutation is significantly associated with the RNA expression of many other genes, with 1,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT5-associated genes across cancer lineages are MIR1261, COPS8P3, and RNU6-249P. Each is linked with CCT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCT5-to-partner and partner-to-CCT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1261 grouped by CCT5-low versus CCT5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT5→partner) and Y-score (partner→CCT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR1261 →	+0.440	+5.438	<.001	.002	3	3
LUSC	COPS8P3 →	+0.310	+5.031	<.001	.002	3	3
HNSC	RNU6-249P →	+0.373	+4.654	.001	.004	3	2
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
CESC	RN7SL575P →	+0.270	+4.551	<.001	.004	3	2
COAD	RPL32P17 →	+0.495	+2.785	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,443 associations by consensus.

MIR1261 by CCT5 expression — LUSC

Explore this box plot interactively →