CCT5

Across TCGA patient cohorts, CCT5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT5-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Acetyl-a-Tubulin-Lys40. Each is linked with CCT5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCT5-to-partner and partner-to-CCT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCT5-low versus CCT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT5→partner) and Y-score (partner→CCT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.575	-2.584	.006	.011	3	4
UCEC	Caspase-7-cleavedD198 →	+0.602	+3.019	.029	.019	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.473	+2.179	.046	.034	3	1
UCEC	Ku80 →	+0.228	+2.598	.038	.006	3	1
UCEC	A-Raf_pS299 →	-0.159	-3.169	.004	.019	2	1
UCEC	Annexin-1 →	+0.516	+2.827	.035	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ATM by CCT5 expression — UCEC

Explore this box plot interactively →