Across TCGA pan-cancer cohorts, CCT4P2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCT4P2’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CCT4P2 RNA is repressed in tumor relative to normal tissue. In most cancer types CCT4P2 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.
LUSC, STAD, and THCA are the cancer types where CCT4P2 tumor–normal differential expression is most reproducible.