CCT4

Across TCGA patient cohorts, CCT4 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,123 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CCT4-associated proteins across cancer lineages are UTP15, MSH2, and RRM2. Each is linked with CCT4 in more than 7 cancer types. Because this analysis shows association rather than direction, both CCT4-to-partner and partner-to-CCT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCT4 versus UTP15 in LSCC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT4→partner) and Y-score (partner→CCT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UTP15 →	+0.422	+0.760	<.001	<.001	3	8
LSCC	MSH2 →	+0.605	+0.732	<.001	<.001	3	8
UCEC	RRM2 →	+0.843	+0.731	<.001	.002	3	8
UCEC	MCM2 →	+0.678	+0.688	<.001	.002	3	8
LSCC	MCM2_S139 →	+0.717	+0.698	<.001	<.001	3	8
BRCA	MCM3 →	+0.693	+0.491	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,123 associations by consensus.

CCT4 vs UTP15 — LSCC

Explore this scatter interactively →