CCT4

Across TCGA patient cohorts, CCT4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,434 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CCT4-associated genes across cancer lineages are MRPL18, TCP1, and GTF3C6. Each is linked with CCT4 in more than 6 cancer types. Because this analysis shows association rather than direction, both CCT4-to-partner and partner-to-CCT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCT4 versus MRPL18 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT4→partner) and Y-score (partner→CCT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL18 →	+0.532	+0.133	<.001	.003	3	7
BRCA	TCP1 →	+0.628	+0.251	<.001	<.001	3	7
UCEC	GTF3C6 →	+0.665	+0.244	<.001	<.001	3	7
GBM	MMS22L →	+0.572	+0.161	.001	.002	3	6
OV	MTFR2 →	+0.762	+0.238	.002	.002	3	6
LSCC	CCT6A →	+0.613	+0.174	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,434 associations by consensus.

CCT4 vs MRPL18 — UCEC

Explore this scatter interactively →