CCT4

Across TCGA patient cohorts, CCT4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT4-associated genes across cancer lineages are eEF2, ERK2, and FoxM1. Each is linked with CCT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT4-to-partner and partner-to-CCT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CCT4-low versus CCT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT4→partner) and Y-score (partner→CCT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.453	+3.169	.008	.018	3	1
UCEC	ERK2 →	+0.267	+2.459	.004	.020	3	1
UCEC	FoxM1 →	+0.278	+2.459	.026	.020	3	1
UCEC	JNK2 →	+0.350	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.317	+2.472	.005	.011	3	1
UCEC	MEK1_p_S217_S221 →	-0.393	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by CCT4 expression — UCEC

Explore this box plot interactively →