CCT4

Across TCGA cell cohorts, CCT4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCT4-associated genes across cancer lineages are C1orf87, OR1M1, and OR9A2. Each is linked with CCT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT4-to-partner and partner-to-CCT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf87 grouped by CCT4-low versus CCT4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT4→partner) and Y-score (partner→CCT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C1orf87 →	+0.056	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR1M1 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR9A2 →	+0.018	+5.209	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.378	+3.252	<.001	.009	3	1
LARGE_INTESTINE	PROP1 →	+0.020	+2.791	<.001	.005	3	1
LARGE_INTESTINE	OR2D3 →	+0.020	+3.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C1orf87 by CCT4 expression — BLOOD_Lymphoma

Explore this box plot interactively →