CCT3

Across TCGA patient cohorts, CCT3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT3-associated genes across cancer lineages are MSH6, Notch1, and p27_pT198. Each is linked with CCT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT3-to-partner and partner-to-CCT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CCT3-low versus CCT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT3→partner) and Y-score (partner→CCT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.353	-1.874	.006	.049	3	2
UCEC	Notch1 →	+0.183	+3.469	<.001	.002	3	1
UCEC	p27_pT198 →	+0.111	+2.502	.008	.002	3	1
UCEC	p62 Lck ligand →	+0.337	+1.884	.008	.030	3	1
UCEC	PDCD4 →	-0.466	-2.502	.011	.002	3	1
UCEC	Rad50 →	-0.262	-3.156	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MSH6 by CCT3 expression — UCEC

Explore this box plot interactively →