CCT3

Across TCGA cell cohorts, CCT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,225 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCT3-associated GO terms across cancer lineages are Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Ribosome biogenesis, and DNA replication initiation. Each is linked with CCT3 in more than 18 cancer types. Because this analysis shows association rather than direction, both CCT3-to-partner and partner-to-CCT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by CCT3-low versus CCT3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT3→partner) and Y-score (partner→CCT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.136	+0.899	<.001	<.001	3	19
CNS	Ribosome biogenesis →	+0.098	+0.636	<.001	<.001	3	18
OESOPHAGUS	DNA replication initiation →	+0.159	+0.758	.004	.004	3	18
BONE	rRNA processing →	+0.106	+0.771	.003	.001	3	18
LUNG_SCLC	rRNA metabolic process →	+0.103	+0.679	<.001	<.001	3	17
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.123	+0.905	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,225 associations by consensus.

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by CCT3 expression — OVARY

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