CCT2

Across TCGA patient cohorts, CCT2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCT2-associated genes across cancer lineages are Gab2, MEK1, and Notch1. Each is linked with CCT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCT2-to-partner and partner-to-CCT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by CCT2-low versus CCT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT2→partner) and Y-score (partner→CCT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.318	+2.321	.020	.034	3	1
UCEC	MEK1 →	+0.452	+2.906	.001	.001	3	1
UCEC	Notch1 →	+0.288	+3.247	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.397	+2.331	.001	.003	3	1
UCEC	PDCD4 →	-0.438	-2.087	.015	.005	3	1
UCEC	Annexin-1 →	+0.577	+3.341	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Gab2 by CCT2 expression — UCEC

Explore this box plot interactively →