CCT2

Across TCGA cell cohorts, CCT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,445 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCT2-associated GO terms across cancer lineages are Maturation of 5.8S rRNA, DNA replication initiation, and rRNA processing. Each is linked with CCT2 in more than 17 cancer types. Because this analysis shows association rather than direction, both CCT2-to-partner and partner-to-CCT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA grouped by CCT2-low versus CCT2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCT2→partner) and Y-score (partner→CCT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Maturation of 5.8S rRNA →	+0.113	+0.929	.006	<.001	3	18
BLOOD_Myeloma	DNA replication initiation →	+0.192	+0.941	<.001	<.001	3	17
BONE	rRNA processing →	+0.125	+0.974	<.001	<.001	3	17
LIVER	RNA 5'-end processing →	+0.124	+0.865	.001	<.001	3	17
URINARY_TRACT	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.146	+0.911	<.001	<.001	3	16
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.144	+1.065	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,445 associations by consensus.

Maturation of 5.8S rRNA by CCT2 expression — LIVER

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