CCSER2

Across TCGA patient cohorts, CCSER2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCSER2-associated genes across cancer lineages are c-Met_pY1235, Cyclin-B1, and MSH2. Each is linked with CCSER2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCSER2-to-partner and partner-to-CCSER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by CCSER2-low versus CCSER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCSER2→partner) and Y-score (partner→CCSER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.083	+1.687	<.001	.013	3	3
UCEC	Cyclin-B1 →	+0.652	+3.906	<.001	<.001	3	3
UCEC	MSH2 →	-0.213	-2.433	.005	.018	3	2
UCEC	TFRC →	+0.587	+2.201	<.001	<.001	2	3
UCEC	TIGAR →	+0.125	+1.348	.014	.018	3	2
UCEC	4E-BP1 →	+0.404	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

c-Met_pY1235 by CCSER2 expression — UCEC

Explore this box plot interactively →