CCSAP

Across TCGA cell cohorts, CCSAP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,573 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCSAP-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of mitotic metaphase/anaphase transition, and Regulation of sister chromatid segregation. Each is linked with CCSAP in more than 15 cancer types. Because this analysis shows association rather than direction, both CCSAP-to-partner and partner-to-CCSAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by CCSAP-low versus CCSAP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCSAP→partner) and Y-score (partner→CCSAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.139	+0.766	<.001	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.141	+0.785	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.138	+0.859	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.145	+0.843	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.175	+0.750	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle organization →	+0.115	+0.857	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,573 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by CCSAP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →