CCS

Across TCGA pan-cancer cohorts, CCS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CCS data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CCS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCS expression acts as an unfavorable survival marker.

COAD, UCEC, and SKCM are the cancer types where CCS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.164	0.783	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.216	0.705	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CCS–COAD (DFS)

Open the COAD breakdown →