CCS

Across TCGA patient cohorts, CCS RNA expression is significantly associated with the protein abundance of many other proteins, with 8,629 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CCS-associated proteins across cancer lineages are SAMSN1, TOMM34, and RBM4. Each is linked with CCS in more than 3 cancer types. Because this analysis shows association rather than direction, both CCS-to-partner and partner-to-CCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCS versus SAMSN1 in LSCC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CCS→partner) and Y-score (partner→CCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMSN1 →	-0.459	-0.289	<.001	.007	3	4
LSCC	TOMM34 →	+0.478	+0.339	<.001	<.001	3	4
CCRCC	RBM4 →	+0.295	+0.280	<.001	.001	3	3
LSCC	RSF1 →	+0.243	+0.286	<.001	<.001	3	3
CCRCC	SAMSN1_S347 →	-0.610	-0.361	.001	.004	3	3
CCRCC	SASH3 →	-0.334	-0.349	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,629 associations by consensus.

CCS vs SAMSN1 — LSCC

Explore this scatter interactively →