CCS

Across TCGA patient cohorts, CCS protein abundance is significantly associated with the RNA expression of many other genes, with 8,295 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CCS-associated genes across cancer lineages are ARPC5L, MYBL2, and PPIF. Each is linked with CCS in more than 3 cancer types. Because this analysis shows association rather than direction, both CCS-to-partner and partner-to-CCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCS versus ARPC5L in HNSC, with a Pearson correlation of -0.22.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCS→partner) and Y-score (partner→CCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARPC5L →	-0.445	-0.249	<.001	<.001	3	4
BRCA	MYBL2 →	-1.099	-0.222	.001	.003	3	4
CCRCC	PPIF →	-0.612	-0.240	.003	.003	3	4
BRCA	KIF2C →	-0.832	-0.230	.004	.002	3	4
GBM	POC1A →	-0.562	-0.215	.001	.008	3	4
CCRCC	PARPBP →	-0.520	-0.314	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,295 associations by consensus.

CCS vs ARPC5L — HNSC

Explore this scatter interactively →