CCS

Across TCGA patient cohorts, CCS mutation is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCS-associated genes across cancer lineages are MIR4418, MIR3689D2, and RN7SL282P. Each is linked with CCS in more than 1 cancer types. Because this analysis shows association rather than direction, both CCS-to-partner and partner-to-CCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4418 grouped by CCS-low versus CCS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCS→partner) and Y-score (partner→CCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4418 →	+0.551	+4.308	<.001	.009	3	2
LUAD	MIR3689D2 →	+0.460	+7.930	<.001	.008	3	2
SKCM	RN7SL282P →	+0.171	+4.594	<.001	.008	3	1
COAD	RNU6-379P →	+0.517	+3.717	.007	.008	3	1
COAD	RNY3P7 →	+0.310	+5.332	<.001	.002	3	1
COAD	MIR1305 →	+0.317	+4.418	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

MIR4418 by CCS expression — COAD

Explore this box plot interactively →