CCS

Across TCGA cell cohorts, CCS RNA expression is significantly associated with the RNA expression of many other genes, with 9,564 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CCS-associated genes across cancer lineages are BBS1, RAD9A, and ANKRD13D. Each is linked with CCS in more than 17 cancer types. Because this analysis shows association rather than direction, both CCS-to-partner and partner-to-CCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCS versus BBS1 in BONE, with a Pearson correlation of 0.72.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCS→partner) and Y-score (partner→CCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BBS1 →	+1.380	+1.035	<.001	<.001	3	18
LIVER	RAD9A →	+2.187	+1.619	<.001	.002	3	16
LIVER	ANKRD13D →	+2.330	+1.654	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	INPPL1 →	+1.549	+1.327	.001	<.001	3	16
KIDNEY	APBB3 →	+1.503	+1.103	<.001	<.001	3	14
OESOPHAGUS	PCSK4 →	+2.019	+1.299	<.001	.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,564 associations by consensus.

CCS vs BBS1 — BONE

Explore this scatter interactively →