CCS

Across TCGA cell cohorts, CCS mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCS-associated genes across cancer lineages are GFRA4, OR10K2, and MC2R. Each is linked with CCS in more than 1 cancer types. Because this analysis shows association rather than direction, both CCS-to-partner and partner-to-CCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by CCS-low versus CCS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCS→partner) and Y-score (partner→CCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	MC2R →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.889	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.909	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GFRA4 by CCS expression — BLOOD_Leukemia

Explore this box plot interactively →