CCR7

Across TCGA patient cohorts, CCR7 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCR7-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and MIG-6. Each is linked with CCR7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR7-to-partner and partner-to-CCR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CCR7-low versus CCR7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR7→partner) and Y-score (partner→CCR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.107	-1.700	.043	.044	3	1
UCEC	MEK1 →	+0.404	+2.222	.009	.011	3	1
UCEC	MIG-6 →	+0.100	+3.169	.018	.018	3	1
UCEC	MSH2 →	-0.252	-2.312	.010	.034	3	1
UCEC	mTOR_pS2448 →	-0.141	-2.439	.026	.019	3	1
UCEC	p62 Lck ligand →	+0.415	+1.884	.002	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by CCR7 expression — UCEC

Explore this box plot interactively →