CCR7

Across TCGA cell cohorts, CCR7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,945 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCR7-associated GO terms across cancer lineages are Regulation of dendritic cell dendrite assembly, C-C chemokine receptor CCR7 signaling pathway, and Chemokine (C-C motif) ligand 21 signaling pathway. Each is linked with CCR7 in more than 17 cancer types. Because this analysis shows association rather than direction, both CCR7-to-partner and partner-to-CCR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of dendritic cell dendrite assembly grouped by CCR7-low versus CCR7-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR7→partner) and Y-score (partner→CCR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of dendritic cell dendrite assembly →	+1.883	+5.380	<.001	<.001	3	18
BLOOD_Lymphoma	C-C chemokine receptor CCR7 signaling pathway →	+1.883	+5.380	<.001	<.001	3	18
URINARY_TRACT	Chemokine (C-C motif) ligand 21 signaling pathway →	-0.174	-0.561	<.001	<.001	3	10
BREAST	Positive regulation of phospholipase C/protein kinase C signal transduction →	-0.341	-0.544	<.001	<.001	3	9
URINARY_TRACT	Establishment of lymphocyte polarity →	-0.177	-0.658	<.001	.002	3	8
SOFT_TISSUE	Establishment of T cell polarity →	-0.293	-0.389	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,945 associations by consensus.

Regulation of dendritic cell dendrite assembly by CCR7 expression — BLOOD_Lymphoma

Explore this box plot interactively →