CCR6

Across TCGA patient cohorts, CCR6 mutation is significantly associated with the RNA expression of many other genes, with 1,799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCR6-associated genes across cancer lineages are UQCRH, ZNF530, and KLHL25. Each is linked with CCR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCR6-to-partner and partner-to-CCR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by CCR6-low versus CCR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR6→partner) and Y-score (partner→CCR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRH →	+0.803	+3.839	.003	<.001	3	3
UCEC	ZNF530 →	+0.417	+2.753	<.001	.002	3	2
UCEC	KLHL25 →	+0.466	+2.136	.002	.009	3	2
UCEC	PNMA3 →	-1.062	-3.542	.003	.002	3	2
UCEC	UQCR10 →	+0.415	+3.711	<.001	<.001	3	2
UCEC	NDUFA6 →	+0.631	+2.403	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,799 associations by consensus.

UQCRH by CCR6 expression — UCEC

Explore this box plot interactively →