CCR6

Across TCGA patient cohorts, CCR6 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCR6-associated genes across cancer lineages are PRAS40_pT246, ASNS, and ATM. Each is linked with CCR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR6-to-partner and partner-to-CCR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by CCR6-low versus CCR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR6→partner) and Y-score (partner→CCR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.157	+1.691	.017	.014	3	2
UCEC	ASNS →	+0.390	+1.906	.004	.015	3	2
UCEC	ATM →	-0.563	-2.459	.001	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.587	+1.720	.009	.025	3	2
UCEC	4E-BP1 →	+0.420	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.096	-2.558	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PRAS40_pT246 by CCR6 expression — UCEC

Explore this box plot interactively →