CCR5

Across TCGA patient cohorts, CCR5 mutation is significantly associated with the RNA expression of many other genes, with 2,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCR5-associated genes across cancer lineages are BLOC1S2, MRPL18, and RNU6-182P. Each is linked with CCR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCR5-to-partner and partner-to-CCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BLOC1S2 grouped by CCR5-low versus CCR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR5→partner) and Y-score (partner→CCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BLOC1S2 →	+0.443	+2.148	<.001	<.001	3	3
UCEC	MRPL18 →	+0.357	+2.233	<.001	.005	3	3
LIHC	RNU6-182P →	+0.299	+5.479	<.001	.002	3	2
BLCA	RN7SKP181 →	+0.201	+4.685	<.001	<.001	3	2
BLCA	RNU7-67P →	+0.753	+4.147	<.001	.009	3	2
SKCM	RRM1-AS1 →	+0.163	+2.724	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,660 associations by consensus.

BLOC1S2 by CCR5 expression — UCEC

Explore this box plot interactively →