CCR5

Across TCGA cell cohorts, CCR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 931 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCR5-associated GO terms across cancer lineages are Negative regulation of innate immune response, Vesicle fusion with vacuole, and Nuclear membrane organization. Each is linked with CCR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCR5-to-partner and partner-to-CCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of innate immune response grouped by CCR5-low versus CCR5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR5→partner) and Y-score (partner→CCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of innate immune response →	+0.066	+0.018	.001	.002	3	4
BLOOD_Leukemia	Vesicle fusion with vacuole →	+0.071	+0.373	<.001	.005	3	4
BLOOD_Leukemia	Nuclear membrane organization →	+0.057	+0.467	<.001	.008	3	4
LARGE_INTESTINE	Plasma membrane repair →	+0.071	+0.015	.009	.004	2	4
BLOOD_Lymphoma	Positive regulation of protein localization to cilium →	-0.056	-1.091	<.001	.001	3	3
BLOOD_Lymphoma	Positive regulation of dendrite extension →	-0.068	-1.564	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 931 associations by consensus.

Negative regulation of innate immune response by CCR5 expression — STOMACH

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