Across TCGA patient cohorts, CCR4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCR4-associated genes across cancer lineages are FoxM1, PDCD4, and eIF4E. Each is linked with CCR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR4-to-partner and partner-to-CCR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR4→partner) and Y-score (partner→CCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.236	+3.000	.027	.001	3	2
UCEC	PDCD4 →	-0.567	-2.321	.003	.006	3	2
UCEC	eIF4E →	+0.184	+2.321	.034	.006	3	1
UCEC	eIF4G →	+0.283	+1.807	.027	.027	3	1
UCEC	A-Raf_pS299 →	-0.099	-2.459	.044	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.183	-3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

CCR4 survival (RNA) · tumor vs normal (RNA) · all CCR4 data types