CCR2

Across TCGA cell cohorts, CCR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,574 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCR2-associated GO terms across cancer lineages are Regulation of immune complex clearance by monocytes and macrophages, Regulation of calcium ion export across plasma membrane, and Amino-acid betaine biosynthetic process. Each is linked with CCR2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CCR2-to-partner and partner-to-CCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of immune complex clearance by monocytes and macrophages grouped by CCR2-low versus CCR2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR2→partner) and Y-score (partner→CCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of immune complex clearance by monocytes and macrophages →	+1.688	+2.921	<.001	<.001	3	10
BLOOD_Leukemia	Regulation of calcium ion export across plasma membrane →	+0.050	+1.325	<.001	<.001	3	6
BLOOD_Myeloma	Amino-acid betaine biosynthetic process →	-0.108	-2.753	.003	.005	3	5
PANCREAS	Regulation of type I interferon-mediated signaling pathway →	+0.081	+0.042	<.001	.003	3	5
SKIN	Endosomal transport →	+0.029	+0.021	.007	.002	3	4
PANCREAS	Regulation of ATP metabolic process →	+0.042	+0.043	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,574 associations by consensus.

Regulation of immune complex clearance by monocytes and macrophages by CCR2 expression — BLOOD_Myeloma

Explore this box plot interactively →