CCR2

Across TCGA cell cohorts, CCR2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCR2-associated genes across cancer lineages are PAX4, ADRA1A, and CFHR5. Each is linked with CCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR2-to-partner and partner-to-CCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by CCR2-low versus CCR2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR2→partner) and Y-score (partner→CCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAX4 →	+0.017	+4.276	<.001	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.214	+4.705	<.001	.003	3	1
BLOOD_Leukemia	CFHR5 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	GH2 →	+0.021	+4.969	<.001	.003	3	1
BLOOD_Leukemia	PDHA2 →	+0.024	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GPR101 →	+0.141	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PAX4 by CCR2 expression — BLOOD_Leukemia

Explore this box plot interactively →