CCP110

Across TCGA patient cohorts, CCP110 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCP110-associated genes across cancer lineages are MEK1, CDK1, and Notch1. Each is linked with CCP110 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCP110-to-partner and partner-to-CCP110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CCP110-low versus CCP110-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCP110→partner) and Y-score (partner→CCP110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.409	+2.459	.001	<.001	3	3
SKCM	CDK1 →	+0.355	+3.000	<.001	.035	3	3
UCEC	Notch1 →	+0.147	+2.232	.002	.005	3	2
UCEC	PDCD4 →	-0.591	-2.077	<.001	.005	3	2
UCEC	ATM →	-0.492	-1.736	.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.634	+2.522	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by CCP110 expression — UCEC

Explore this box plot interactively →