CCNY

Across TCGA patient cohorts, CCNY mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNY-associated genes across cancer lineages are HER3_pY1289, p70-S6K_pT389, and Bak. Each is linked with CCNY in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNY-to-partner and partner-to-CCNY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by CCNY-low versus CCNY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNY→partner) and Y-score (partner→CCNY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.082	+2.479	.012	.010	3	2
UCEC	p70-S6K_pT389 →	-0.257	-2.700	<.001	.005	3	2
UCEC	Bak →	+0.227	+2.115	.018	.016	3	2
UCEC	14-3-3_beta →	-0.094	-2.295	.014	.033	3	1
UCEC	EGFR_pY1068 →	-0.298	-2.087	.001	.005	3	1
UCEC	FoxM1 →	+0.300	+2.584	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

HER3_pY1289 by CCNY expression — UCEC

Explore this box plot interactively →