CCNQ

Across TCGA patient cohorts, CCNQ mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNQ-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Notch1. Each is linked with CCNQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNQ-to-partner and partner-to-CCNQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CCNQ-low versus CCNQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNQ→partner) and Y-score (partner→CCNQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.175	-1.687	.014	.044	3	1
UCEC	Ku80 →	+0.313	+2.920	.001	.001	3	1
UCEC	Notch1 →	+0.208	+2.594	<.001	.006	3	1
UCEC	PDCD4 →	-0.580	-1.990	.003	.030	3	1
UCEC	Annexin-1 →	+0.657	+2.479	.003	.010	3	1
UCEC	Syk →	+0.321	+2.235	.043	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK_pT183_Y185 by CCNQ expression — UCEC

Explore this box plot interactively →