CCNP

Across TCGA patient cohorts, CCNP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNP-associated genes across cancer lineages are Bax, MSH6, and TAZ. Each is linked with CCNP in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNP-to-partner and partner-to-CCNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by CCNP-low versus CCNP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNP→partner) and Y-score (partner→CCNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.433	+2.817	.001	.036	3	2
UCEC	MSH6 →	-0.507	-3.000	.007	.037	3	1
UCEC	TAZ →	+0.220	+3.000	.007	.037	3	1
UCEC	4E-BP1 →	+0.333	+2.837	.033	.035	3	1
UCEC	MEK1 →	+0.548	+3.000	.009	.037	2	1
UCEC	DJ-1 →	+0.244	+3.000	.011	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Bax by CCNP expression — UCEC

Explore this box plot interactively →