Across TCGA patient cohorts, CCNL2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNL2-associated genes across cancer lineages are EGFR_pY1068, Lck, and MSH6. Each is linked with CCNL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNL2-to-partner and partner-to-CCNL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNL2→partner) and Y-score (partner→CCNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.584	.010	.001	3	2
UCEC	Lck →	+0.219	+1.678	.004	.023	3	2
UCEC	MSH6 →	-0.451	-2.105	<.001	.017	3	2
UCEC	Rab25 →	-0.365	-1.678	.004	.023	3	2
UCEC	Annexin-1 →	+0.650	+2.135	.001	.010	3	2
UCEC	Shc_pY317 →	-0.169	-3.807	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

CCNL2 survival (RNA) · tumor vs normal (RNA) · all CCNL2 data types