CCNH

Across TCGA patient cohorts, CCNH mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNH-associated genes across cancer lineages are EGFR_pY1068, ACC1, and Shc_pY317. Each is linked with CCNH in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNH-to-partner and partner-to-CCNH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCNH-low versus CCNH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNH→partner) and Y-score (partner→CCNH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.227	-2.115	.038	.019	3	2
UCEC	ACC1 →	+0.351	+3.013	.027	.018	3	2
UCEC	Shc_pY317 →	-0.134	-2.459	.043	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.577	+2.189	.026	.034	3	2
UCEC	SETD2 →	-0.194	-2.807	.042	.003	3	1
UCEC	Caspase-8 →	-0.241	-2.295	.028	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by CCNH expression — UCEC

Explore this box plot interactively →