CCNE1

Across TCGA patient cohorts, CCNE1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNE1-associated genes across cancer lineages are EGFR_pY1068, Annexin-1, and TSC1. Each is linked with CCNE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNE1-to-partner and partner-to-CCNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCNE1-low versus CCNE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNE1→partner) and Y-score (partner→CCNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.213	-1.415	.014	.043	3	2
UCEC	Annexin-1 →	+0.577	+2.434	.001	.001	3	2
UCEC	TSC1 →	-0.150	-1.661	.011	.040	3	2
UCEC	ATM →	-0.720	-2.459	<.001	<.001	3	2
UCEC	CD20 →	+0.100	+1.605	.027	.020	3	2
UCEC	eEF2 →	+0.312	+1.440	.011	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by CCNE1 expression — UCEC

Explore this box plot interactively →