CCND1

Across TCGA pan-cancer cohorts, CCND1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCND1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CCND1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCND1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, LSCC, and HNSC are the cancer types where CCND1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCND1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+1.584	<.001	12	view →
LSCC	All	III,IV	−0.584	<.001	7	view →
HNSC	Male	III,IV	+0.444	<.001	6	view →
LUAD	Female	III,IV	−0.253	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CCND1–CCRCC

Open the CCRCC breakdown →