CCND1

Across TCGA patient cohorts, CCND1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCND1-associated genes across cancer lineages are Fibronectin, 14-3-3_beta, and GATA3. Each is linked with CCND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCND1-to-partner and partner-to-CCND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CCND1-low versus CCND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCND1→partner) and Y-score (partner→CCND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.258	-2.105	.033	.017	3	2
UCEC	14-3-3_beta →	-0.094	-1.847	.011	.049	3	1
UCEC	GATA3 →	-0.175	-2.321	.011	.033	3	1
UCEC	ACC1 →	+0.366	+1.847	.006	.008	3	1
UCEC	JNK2 →	+0.176	+1.710	.015	.025	3	1
UCEC	Ku80 →	+0.250	+2.331	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Fibronectin by CCND1 expression — UCEC

Explore this box plot interactively →