CCNC

Across TCGA pan-cancer cohorts, CCNC mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CCNC data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CCNC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCNC expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where CCNC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.150	0.771	.001	17	view →
LSCC	OS	Tertile	All	0.884	0.665	.006	14	view →
LUAD	OS	Median	III,IV	0.879	0.454	.016	13	view →
HNSC	OS	Quartile	III,IV	0.729	0.956	.008	10	view →
PDAC	DFS	Median	All	0.203	0.550	.010	6	view →
GBM	DFS	Median	All	0.137	0.734	.017	5	view →
UCEC	DFS	Median	All	0.917	0.780	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CCNC–CCRCC (DFS)

Open the CCRCC breakdown →