CCNB2

Across TCGA patient cohorts, CCNB2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNB2-associated genes across cancer lineages are JNK2, MEK1, and p62 Lck ligand. Each is linked with CCNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNB2-to-partner and partner-to-CCNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CCNB2-low versus CCNB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNB2→partner) and Y-score (partner→CCNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.220	+3.584	.022	.002	3	1
UCEC	MEK1 →	+0.434	+3.321	.014	.010	3	1
UCEC	p62 Lck ligand →	+0.324	+3.009	.039	.019	3	1
UCEC	VHL →	-1.087	-2.459	<.001	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.862	+2.341	.002	.019	3	1
UCEC	C-Raf →	+0.189	+3.000	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by CCNB2 expression — UCEC

Explore this box plot interactively →